Science can do everything? Some time I feel this is real and this time Scientists create fully-functional brain neurons from mouse skin cells. Next Steps is clone same method for Human Brain and that will be a moment were we can say this is the time were Scientist has achieved another millstone.
It is a very good reason for you to shoehorn Pinky and the Human brain onto the site, yet scientists have got managed to graft neurons reprogrammed via pores and skin tissue to the heads connected with these rodents. It isn’t really the 1st time that has been carried out, yet it’s the very first time that the particular experts have had virtually any fortune with all the neurons making it through straight into long-term stability. On top of that, 6 months after implantation, the particular neurons got become fully-functional inside the head. Cell phone substitute therapy would be able to handle neurodegenerative diseases like Parkinson’s, replacing non-working neurons using completely new tissue reprogrammed via elsewhere.
Scientists from the University of Luxembourg have for the first time successfully grafted neurons reprogrammed from skin cells into the brains of mice, obtaining long term stability; six months after the procedure, the neurons were fully integrated into the brain. This procedure raises new hopes for replacing sick neurons with new ones, especially for patients suffering from degenerative diseases such as Parkinson’s.
What is Parkinson?
Parkinson’s disease is a progressive disorder of the nervous system that affects your movement. It develops gradually, sometimes starting with a barely noticeable tremor in just one hand. But while a tremor may be the most well-known sign of Parkinson’s disease, the disorder also commonly causes stiffness or slowing of movement.
In the early stages of Parkinson’s disease, your face may show little or no expression or your arms may not swing when you walk. Your speech may become soft or slurred. Parkinson’s disease symptoms worsen as your condition progresses over time.
Although Parkinson’s disease can’t be cured, medications may markedly improve your symptoms. In occasional cases, your doctor may suggest surgery to regulate certain regions of your brain and improve your symptoms.
Scientists create fully-functional brain neurons from mouse skin cells Continued…
The group was led by Prof. Dr. Jens Schwamborn and Kathrin Hemmer and is focused around finding solutions for people suffering from currently untreatable degenerative diseases. Their answer was to simply replace the old, sick neurons, with new ones, and see if it works. So far, their technique has proven successful in mice, but even with such promising results, there’s still a long way before human treatment can be discussed.
“Successes in human therapy are still a long way off, but I am sure successful cell replacement therapies will exist in future. Our research results have taken us a step further in this direction,” declares stem cell researcher Prof. Schwamborn, who heads a group of 15 scientists at LCSB.
In order to do this, they reprogrammed skin cells to act as neurons, creating stable nerve tissue in the brain. Their technique of using cells from the same mouse (skin cells) drastically improves the compatibility of the implanted cells. Even in the initial results, 6 months after the implantation, mice showed to signs of rejection or incompatibility. Furthermore, the neurons exhibited normal activity and were connected to the original brain cells via newly formed synapses, the contact points between nerve cells.
Again, these are just the initial results, but scientists are confident in further developing the technique and implementing it in humans – something which they believe will happen relatively soon. In the future, implanted neurons could produce dopamine and/or transport it in the brain. This is the next step in their research.
“Building upon the current insights, we will now be looking specifically at the type of neurons that die off in the brain of Parkinson’s patients – namely the dopamine-producing neurons,” Schwamborn reports.
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